The rapid development of electronic skins has allowed novel multifunctional human–machine interaction interfaces, especially in motion interaction sensors. Although motion sensing is widely used in advanced flexible electronic devices through the integration of single sensing units, the number of electrodes has increased with the increase in integration by the square multiple. This talk will focus on self-powered electronic skin based on triboelectric effect, start with high performance TENG based hybrid nanogenerator, then multi-functional active sensors and actuators based on the same principle, including the method to mimic human skin with stretch ability and conductivity. Furthermore, biocompatibility, self-healing and humidity-resistance are also stated. Finally, some demonstrations of self-powered e-skin, for example, skin-on-chip, smart watch, health monitor patch, will be introduced. The perspective of this field will be discussed in the last.